Journal article

Dual-responsive nanoparticles constructed using light- and redox-responsive linkages

Yufu Wang, Changhe Zhang, Manjiri Choudhari, Sarah S Kermaniyan, Chris Ritchie, Georgina K Such

Polymer Chemistry | Royal Society of Chemistry | Published : 2024

Abstract

Stimuli-responsive nanoparticles have garnered significant interest for advanced materials design and development in areas such as biomedicine, sensing, and energy. Recent studies have demonstrated that integrating multiple functionalities into a single nanoparticle structure is a crucial approach for engineering multi-responsive properties. In this study, light- and redox-responsive nanoparticles were synthesized using a simple one-pot emulsion polymerization utilizing mild thiol-disulfide exchange reactions to direct the self-assembly process. Poly(disulfide) bonds were formed during this process and comprised the core part of the nanoparticles, enabling redox responsiveness upon disulfide..

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University of Melbourne Researchers

Grants

Awarded by ARC Future Fellowship Scheme


Awarded by ARC Centre of Excellence for Enabling Eco-Efficient Beneficiation of Minerals


Awarded by ARC Research Council Discovery Program


Awarded by Australian Research Council


Funding Acknowledgements

C. R. would like to acknowledge financial support from the ARC Future Fellowship Scheme for funding this research (FT180100610) and the ARC Centre of Excellence for Enabling Eco-Efficient Beneficiation of Minerals (Grant No. CE200100009). G. S. would like to acknowledge funding through the ARC Research Council Discovery Program (DP210103174). Y. W. would like to acknowledge Dr Hamish Brown and the Bio21 Lan Holmes Imaging Centre for support with Cryo-EM. Y. W. would like to acknowledge the support of the University of Melbourne through the Melbourne Research Scholarship. M. C. would like to thank the School of Chemistry, Monash University, for DPRS and DIPRS scholarships.